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When investigated, the altered hormonal profile caused by prohormone intake is similar to the hormonal profiles observed in men with gynecomastia, prostate cancer, testicular cancer, and pancreatic cancer. Whether the prolonged use of prohormones results in these end outcomes is difficult to distinguish (because of poor quality studies and the ethical hurdle of performing a study directly investigating this link) however, anecdotally, cases have been reported and associated with prohormone use, bodybuilding prohormones 2022. Additionally, prolonged ingestion of androstenedione or androstenediol has been shown to reduce levels of “good” cholesterol within 1 week of use.
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