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Clenbuterol and carvedilol treatments enhanced the absolute contractile force of skeletal muscle ( ), and when normalized by either CSA ( ). The nonnormalized effects of carvedilol and clenbuterol were abolished in βarr1smKO mice ( ), and were markedly diminished (carvedilol) or completed abrogated (clenbuterol) when normalized to CSA (. Beta receptors can be blocked by using synthetic drugs, but B2-selective blockers are yet to be found. We present a case of a 22-year-old bodybuilder diagnosed with myocarditis secondary to clenbuterol use. Results The patient was primarily managed conservatively by the discontinuation of clenbuterol and the temporary use of dual anti-platelets, beta-blockers and nitrates. Extremely selective beta blockers like nebivolol will cancel out the heart wrangling and high blood pressure effects of clen but not the weight loss or other good side effects. Non-selective beta blockers like propranolol would work to cancel out all of the effects of clen or other beta agonists. Evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy. P A MacLennan and R H Edwards Author information Copyright and License information Disclaimer Abstract 1. Beta blockers to prevent clenbuterol poisoning Lancet
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