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For example, stronger and stiffer tendons have been observed with aging [133,163,164], while other studies have shown weaker and more compliant tendons [165,166,167,168], nitric oxide dangers. Furthermore, aging seems to affect the viscoelastic properties of tendons [169,170]. Relevant age-dependent differences in ultimate stress, relaxation rate, and percent relaxation were observed in the tail tendon of old rats, where relaxation rate and percent relaxation decreased with age [167]. As mechanical properties of the tendon influence the muscle-tendon unit function [5], it is worth investigating the underlying events of aging-associated tendon development, particularly ECM remodeling.
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The difference between these two studies and ours could be due to examining hypertensive animals in those two studies, while animals were normotensive in our study, and it is evident that treatment protocols such as drugs and exercise can be more effective upon hypertensive animals compared with normotensive ones. Of course, in contrast to our study, BP was measured in conscious mode, animals had hypertension, and nandrolone dose in Tseng et al, nitric oxide dangers. Regarding the effect of chronic administration of nandrolone and exercise on HR, most of similar studies reported lack of significant effect of exercise (46, 47, 49) or chronic administration of nandrolone (48, 50) on HR of rats. Natural alternative to prednisone steroids
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